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A Multidisciplinary Study of Breast Cancer in Ghana: Pilot Phase

18 Years
74 Years
Open (Enrolling)
Breast Neoplasms

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Trial Information

A Multidisciplinary Study of Breast Cancer in Ghana: Pilot Phase

Breast cancer is becoming a more common disease in Africa, with a high proportion of cases
developing among women under age 35. Despite this, there is scant information on
predisposing factors in African populations. We are proposing a multidisciplinary
case-control study in two teaching hospitals in Accra and Kumasi that treat the majority of
breast cancers in Ghana. Over the three year study period, it is anticipated that
approximately 1,500 cases and 3,000 population controls will be accrued between the two
sites. The investigation will be preceded by an intensive one year pilot phase where the
feasibility of planned study efforts will be assessed. Tumor tissue samples will also be
sought from cases in order to classify them into subtypes (including triple negative tumors,
which predominate among young African women). A detailed questionnaire will be administered
in hospital, and subjects will be asked to donate blood, saliva, and stool samples for
assessment of genetic and other biologic markers. Similar materials will be collected from
population controls, who will be identified through the 2010 Ghanaian Census. In addition
to providing unique data relevant for improving prevention activities, this study will build
capacity for additional research activities in Ghana.

Inclusion Criteria


- Eligible for inclusion as cases in this study will be women, 18-74 years of age, who
have been residents of defined catchment areas in the two cities for at least one
year's time and who are either diagnosed at the study hospitals (KBTH and KATH) or
referred there for clinical care. The catchment area in Accra will consist of 10
districts in greater Accra (Accra, Adenta, Tema, Ashaiman, GaEast, GaWest,
Ledzekuku-Krowor, Weija, Dangme East, Dangme West), 2 in the eastern region (Suhum
Kraboa Coaltar, Akuapem south) and 1 in the central region (Awutu Senya).

- We do not anticipate excluding any breast cancer patients in Accra due to residency
other than those who have recently migrated into the city. In Kumasi, we will be
excluding some patients based on district of residence, although the vast majority of
those coming to KATH for a diagnosis should be coming from the nearby areas.

Type of Study:


Study Design:

Time Perspective: Prospective

Principal Investigator

Louise Brinton, Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Cancer Institute (NCI)


United States: Federal Government

Study ID:




Start Date:

July 2012

Completion Date:

Related Keywords:

  • Breast Neoplasms
  • Breast Cancer
  • Epidemiology
  • Breast Neoplasms
  • Neoplasms