A Multidisciplinary Study of Breast Cancer in Ghana: Pilot Phase
Breast cancer is becoming a more common disease in Africa, with a high proportion of cases
developing among women under age 35. Despite this, there is scant information on
predisposing factors in African populations. We are proposing a multidisciplinary
case-control study in two teaching hospitals in Accra and Kumasi that treat the majority of
breast cancers in Ghana. Over the three year study period, it is anticipated that
approximately 1,500 cases and 3,000 population controls will be accrued between the two
sites. The investigation will be preceded by an intensive one year pilot phase where the
feasibility of planned study efforts will be assessed. Tumor tissue samples will also be
sought from cases in order to classify them into subtypes (including triple negative tumors,
which predominate among young African women). A detailed questionnaire will be administered
in hospital, and subjects will be asked to donate blood, saliva, and stool samples for
assessment of genetic and other biologic markers. Similar materials will be collected from
population controls, who will be identified through the 2010 Ghanaian Census. In addition
to providing unique data relevant for improving prevention activities, this study will build
capacity for additional research activities in Ghana.
Observational
Time Perspective: Prospective
Louise Brinton, Ph.D.
Principal Investigator
National Cancer Institute (NCI)
United States: Federal Government
999912174
NCT01661023
July 2012
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