Inclusion Criteria:

- Histologically confirmed breast cancer

- Pretreated metastatic breast cancer not more than 2 lines chemotherapy

- Have not been previously treated with capecitabine,oral fluracil

- ECOG performance status of ≤ 1

- Be female and ≥ 18 and ≤ 75 years of age

- Have at least one target lesion according to the RECIST criteria 1.1

Exclusion Criteria:

- Pregnant or lactating women

- ECOG ≥ 2

- Have been treated with capecitabine

- Evidence of CNS metastasis

- History of another malignancy within the last five years except cured basal cell
carcinoma of skin and carcinoma in-situ of uterine cervix or a contralateral breast
cancer

- Abnormal laboratory values: hemoglobin < 10.0 g/dl, absolute neutrophil count <
1.5×10^9/L, platelet count < 100×10^9/L, serum creatinine > upper limit of normal
(ULN), serum bilirubin > ULN, ALT and AST > 5×ULN, AKP > 5×ULN

- Serious uncontrolled intercurrent infection

- Life expectancy of less than 3 months