Inclusion Criteria:

- Patients with histologically proven diagnosis of diffuse large cell B-cell lymphoma
(DLBCL) according to the World Health Organization classification.

- Documented relapse or progression following at least one treatment but a maximum of 2
prior treatments. Prior treatment must have included at least 3 cycles of
anthracycline containing chemotherapy (e.g. CHOP-like)

- Any of the following: at least 1 measurable tumor mass (>1.5 cm x >1.0 cm),
involvement of any organ or bone marrow infiltration

- Subjects 18 years or older

- Subjects (or their legally acceptable representatives) must have signed an informed
consent document indicating that they understand the purpose of and procedures
required for the study and are willing to participate in the study.

- Adequate bone marrow reserve: Platelets of at least 75000/µl, absolute neutrophil
count at least 1500/µl

- Alanine aminotransferase (ALT) < 2.5 x upper limit of normal (ULN); Aspartate
aminotransferase (AST) < 2.5 x ULN, Total bilirubin < 1.5 x ULN

- Calculated creatinine clearance (MDRD) > 70 mL/min

- Eastern Cooperative Oncology Group [ECOG] performance Status < 3

- Female subject must be postmenopausal (for at least 6 months), surgically sterile,
abstinent, or, if sexually active, be practicing an effective method of birth control
(e.g., prescription oral contraceptives, contraceptive injections, intrauterine
device, double-barrier method, contraceptive patch, male partner sterilization)
before entry and throughout the study; and have a negative serum ß-hCG pregnancy test
at screening

Exclusion Criteria:

- Active central nervous System lymphoma. Brain MRI is required only if clinically
indicated

- Pregnancy or breast feeding women

- Lymphoma other than DLBCL

- Severe concomitant disease (e.g. uncontrolled arterial hypertension, heart failure
(NYHA III-IV), uncontrolled diabetes mellitus, pulmonary fibrosis, uncontrolled
hyperlipoproteinemia)

- Active uncontrolled infections including HIV-positivity, active Hep B or C

- Mental status precluding patient's compliance

- Prior treatment with Temsirolimus

- Known CD20 negativity

- Patients refractory to DHAP in a prior treatment line

- Prior autologous or allogeneic stem cell or bone marrow transplantation

- Peripheral neuropathy or neuropathic pain of Grade 2 or worse

- Diagnosed or treated for a malignancy other than NHL except: adequately treated
non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, DCIS of
the breast, or other solid tumors curatively treated with no evidence of disease for
>5 years

- Concurrent treatment with another investigational agent during the conduct of the
trial.

- Concurrent participation in non-treatment studies is not excluded

- Known intolerance to Sirolimus or derivates, Cytarabine, Cisplatine or Rituximab.