A Prospective Randomized Trial Comparing Ulinastatin's Drug Protection in Hepatocellular Carcinoma(HCC)Patients'Postoperative Hepatic Failure
Hepatocellular carcinoma (HCC), a serious disease with high incidence at home and abroad,
still shows a rising trend. Postoperative hepatic failure remains a major reason of liver
resection's failure.
• As broad spectrum of enzyme inhibitors, Ulinastatin has the valid therapeutical effect
of hepatic failure and hepatic ischemia-reperfusion injury in animal experiment. And it
restrain inflammatory mediator to release. But it's lack of clinical evidence that
Ulinastatin reduce the incidence of postoperative hepatic failure in HCC patients The
purpose of the study is to assess the effort for comparing Ulinastatin's drug protection in
patients with hepatocellular carcinoma (HCC) for postoperative hepatic failure and to
evaluate that Ulinastatin can improve survival in HCC patients or not.
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
the overall survival rate of each group
3 years
No
Li Aijun, MD
Study Chair
Eastern Hepatobiliary Surgery Hospital, Second Military Medical University
China: Ministry of Health
EHBH-RCT-2012-001
NCT01643447
May 2012
April 2015
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