Focal Adhesion Kinase Expression in Pediatric Renal Tumors
- To determine whether focal adhesion kinase (FAK) is expressed and if FAK is
phosphorylated in pediatric renal tumors.
OUTLINE: Archived tumor tissue samples are analyzed for FAK expression by
immunohistochemistry (IHC). IHC staining is compared in normal renal tissue, Wilms tumor
(routine and anaplastic), malignant rhabdoid tumor of the kidney, clear cell sarcoma of the
kidney, and mesoblastic nephroma.
PROJECTED ACCRUAL: A total of 40 patient samples will be accrued of the following diagnoses:
10 anaplastic Wilms tumor, 10 malignant rhabdoid tumor of the kidney, 10 clear cell sarcoma
of the kidney, and 10 mesoblastic nephroma.
FAK expression in pediatric renal tumors
Elizabeth A. Beierle, MD
Children's Hospital of Alabama at University of Alabama at Birmingham
United States: Federal Government