Focal Adhesion Kinase Expression in Pediatric Renal Tumors
N/A
N/A
Both
Kidney Cancer
Trial Information
Focal Adhesion Kinase Expression in Pediatric Renal Tumors
OBJECTIVES:
- To determine whether focal adhesion kinase (FAK) is expressed and if FAK is
phosphorylated in pediatric renal tumors.
OUTLINE: Archived tumor tissue samples are analyzed for FAK expression by
immunohistochemistry (IHC). IHC staining is compared in normal renal tissue, Wilms tumor
(routine and anaplastic), malignant rhabdoid tumor of the kidney, clear cell sarcoma of the
kidney, and mesoblastic nephroma.
PROJECTED ACCRUAL: A total of 40 patient samples will be accrued of the following diagnoses:
10 anaplastic Wilms tumor, 10 malignant rhabdoid tumor of the kidney, 10 clear cell sarcoma
of the kidney, and 10 mesoblastic nephroma.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Formalin-fixed, paraffin-embedded tissue samples from patients diagnosed with the
following renal tumors:
- Anaplastic Wilms tumor
- Malignant rhabdoid tumor of the kidney
- Clear cell sarcoma of the kidney
- Mesoblastic nephroma
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
FAK expression in pediatric renal tumors
Safety Issue:
No
Principal Investigator
Elizabeth A. Beierle, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Children's Hospital of Alabama at University of Alabama at Birmingham
Authority:
United States: Federal Government
Study ID:
CDR0000736805
NCT ID:
NCT01642095
Start Date:
August 2012
Completion Date:
Related Keywords:
- Kidney Cancer
- Wilms tumor and other childhood kidney tumors
- clear cell renal cell carcinoma
- rhabdoid tumor of the kidney
- congenital mesoblastic nephroma
- Carcinoma, Renal Cell
- Kidney Neoplasms
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