Inclusion Criteria:

1. Subjects must provide written informed consent prior to performance of study-specific
procedures or assessments, and must be willing to comply with treatment and follow
up.

2. Age ≥ to 75 years old

3. Patient with metastatic cancer among renal cell carcinoma, non small cell lung
cancer, pancreatic neuroendocrine cancer, sarcoma , ovarian cancer , thyroid cancer,
bladder cancer or breast cancers, who cannot receive any treatment with curative
intent.

4. WHO PS ≤ 2,

5. Life expectancy ≥ 3 months,

6. Group 2 (vulnerable) according to SIOG classification,

7. Adequate organ system function as defined in provided Table

Exclusion Criteria:

1. Patient with a history of a prior malignancy with the exception of cervical
intraepithelial neoplasia; basal cell carcinoma of the skin; adequately treated
localized prostate carcinoma with PSA <1.0; or who has undergone potentially curative
therapy with no evidence of that disease for five years, and who is deemed at low
risk for recurrence by his/her treating physician,

2. History or clinical evidence of central nervous system (CNS) metastases or
leptomeningeal carcinomatosis, except for individuals who have previously-treated CNS
metastases, are asymptomatic, and have had no requirement for steroids or
anti-seizure medication for 6 months prior to first dose of study drug.

3. Criteria of group 3 according to SIOG classification,

4. Clinically significant gastrointestinal abnormalities that may increase the risk for
gastrointestinal bleeding including, but not limited to:

•Active peptic ulcer disease

•Known intraluminal metastatic lesion/s with risk of bleeding

•Inflammatory bowel disease (e.g. ulcerative colitis, crohn's disease), or other
gastrointestinal conditions with increased risk of perforation

•History of abdominal fistula, gastrointestinal perforation, or intra abdominal
abscess within 28 days prior to beginning study treatment.

5. Clinically significant gastrointestinal abnormalities that may affect absorption of
investigational product including, but not limited to:

•Malabsorption syndrome

•Major resection of the stomach or small bowel.

6. Presence of uncontrolled infection.

7. Corrected QT interval (QTc) > 480 msecs using Bazett's formula

8. Anti-coagulants treatment (preventive or curative)

9. History of any one or more of the following cardiovascular conditions within the past
6 months:

• Cardiac angioplasty or stenting

• Myocardial infarction

• Unstable angina

• Coronary artery bypass graft surgery

- Symptomatic peripheral vascular disease

- Class III or IV congestive heart failure, as defined by the New York Heart
Association (NYHA)

10. Poorly controlled hypertension

11. History of cerebrovascular accident including transient ischemic attack (TIA),
pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6
months.

12. Prior major surgery or trauma within 28 days prior to first dose of study drug and/or
presence of any non-healing wound, fracture, or ulcer

13. Evidence of active bleeding or bleeding diathesis.

14 Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels

15. Hemoptysis in excess of 2.5 mL (or one half teaspoon) within 8 weeks of first dose of
study drug.

16. Any serious and/or unstable pre-existing medical, psychiatric, or other condition that
could interfere with subject's safety, provision of informed consent, or compliance to
study procedures.

17. Unable or unwilling to discontinue use of prohibited medications list in Appendix 7
for at least 14 days or five half-lives of a drug (whichever is longer) prior to the first
dose of study drug and for the duration of the study

18. Treatment with any of the following anti-cancer therapies:

- radiation therapy, surgery or tumor embolization within 14 days prior to the first
dose of pazopanib OR

- chemotherapy, immunotherapy, biologic therapy, investigational therapy or hormonal
therapy within 14 days or five half-lives of a drug (whichever is longer) prior to
the first dose of pazopanib

19. Any ongoing toxicity from prior anti-cancer therapy that is >Grade 1 and/or that
is progressing in severity, except alopecia.

20. Patient not affiliated with social system in France.

21. Patient deprived of liberty or under guardianship