Inclusion Criteria:

- Stages IIA and IIB FIGO classification.

- Age between 21 to 70 years.

- ECOG performance status 0-1.

- No history of another neoplastic disease.

- Value of Hemoglobin ≥ 9 g / l.

- Total leukocyte count ≥ 3.0 x 109 / L.

- Absolute neutrophil count ≥ 1.5 x 109 / L.

- Platelets ≥ 100,000 x mm3.

- Total bilirubin ≤ 1.5 times ULN, SGOT and SGPT ≤ 2.5 times upper limit of normal.

- Creatinine ≤ 2 mg / dL and creatinine clearance calculated ≥ 60 ml / min(according to
Cockcroft-Gault formula)

- Patients of childbearing age who are using an adequate contraception method during
treatment to prevent pregnancy.

- Life expectancy ≥ 12 months

- Measurable disease

- Informed consent signed by the patient

Exclusion Criteria:

- Pregnancy and lactation period.

- Presence of lymph node metastases or hematogenous extrapelvic known.

- Uncontrolled intercurrent diseases, including active infection, symptomatic
congestive heart failure, unstable angina or cardiac arrhythmia and psychiatric
illness involving incompetence of the patient.

- Other malignancies, with the exception of basal cell carcinoma or other tumor that
appropriate treatment is received showing a disease-free period ≥ 5 years.

- Hepatitis B or C active, positive serology for HIV.

- Atopy history of severe / severe asthma.

- A history of autoimmune disease.

- Presence of significant abnormalities in ECG performed within 14 days prior to
admission.

- Diseases that prevent the patient give informed consent or their ability to
collaborate in the trial.

- Participating in another clinical trial "