Feasibility of Minimal Residual Disease (MRD) Determination in Pediatric B-Lineage ALL Using Deep Sequencing of the Immunoglobulin Heavy Chain Locus
- Assess the feasibility of minimal residual disease (MRD) determination in pediatric
B-lineage acute lymphoblastic leukemia (ALL) using deep sequencing of the
immunoglobulin heavy chain locus.
OUTLINE: Archived blood and tumor tissue samples are analyzed for MDR using deep sequencing
of immunoglobulin heavy chain locus. MDR quantification results are then compared with the
flow cytometry reference methods used in COG studies.
Sensitivity of deep sequencing of the immunoglobulin heavy chain locus in determining MRD in B-lineage ALL
Brent Wood, MD, PhD
Seattle Cancer Care Alliance
United States: Federal Government