Inclusion Criteria:

- Patients must have histologically confirmed metastatic or locally advanced renal cell
carcinoma that is unresectable.

- Patients must have disease that is evaluable by the Response Evaluation Criteria in
Solid Tumors guidelines (RECIST), v1.1. Disease sites must be assessed within 4 weeks
of study entry.

- Patients must have been treated with at least one prior conventional molecularly
targeted therapy in a non-adjuvant setting. Conventional molecularly targeted therapy
will be defined as including pazopanib, sorafenib, sunitinib, temsirolimus, axitinib,
or everolimus.

- A two week wash out is required between the last dose of molecularly targeted therapy
and baseline correlative studies (124I-cG250 PET/CT and bone marrow biopsy). If no
baseline correlative studies will be performed, a wash out of 1 week will be required
prior to the commencement of study therapy. Toxicities from prior therapy must be
resolved to grade 1 or less prior to the start of study therapy.

- Patients may have been treated with surgery or not (i.e., cytoreductive nephrectomy
not required), radiation therapy, chemotherapy, cytokine therapy including interferon
alpha and interleukin-2.

- Patients with treated brain or spinal-associated metastases are eligible but must
have concluded dexamethasone therapy and be considered neurologically stable.

- Age greater or equal to 18 years.

- ECOG performance status less than 1 (Karnofsky greater than 70%)

- Life expectancy greater than 3 months.

- Patients must have normal organ and marrow function

- The effects of CRLX101 and bevacizumab on the developing human fetus are unknown. For
this reason, women of child-bearing potential and men must agree to use adequate
contraception (hormonal, barrier method, abstinence) prior to study entry, for the
duration of study participation, and 4 months after completion of administration of
this combination therapy. Should a woman become pregnant or suspect she is pregnant
while she or her partner is participating in this study, she should inform the
treating physician immediately. Men treated or enrolled on this protocol must also
agree to use adequate contraception prior to the study, for the duration of study
participation, and for 4 months after completion of administration of this
combination therapy.

- Ability to understand and the willingness to sign a written informed consent
document.

Exclusion Criteria:

- Patients who have had conventional chemotherapy or radiotherapy within 2 weeks prior
to entering the study or those who have not yet recovered to grade 1 or less prior
treatment-related adverse events.

- Patients who have had major surgery within the last 4 weeks.

- Prior treatment with bevacizumab or topoisomerase I therapy.

- Patients who are receiving any other investigational therapeutic agent.

- History of allergic reactions attributed to any of the experimental compounds
examined in this study.

- No other active malignancy (inactive / without progression for at least 6 months and
no progression anticipated).

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
serious infection, symptomatic congestive heart failure, unstable angina pectoris,
cardiac arrhythmia, or psychiatric illness/social situations that would limit
compliance with study requirements.

- History of non-healing wounds or ulcers.

- Pregnant or nursing patients as stated above. Agents examined in this clinical trial
carry the potential for teratogenic or abortifacient effects. Because there is an
unknown but potential risk for adverse events in nursing infants secondary to
treatment of the mother with study agents, breastfeeding should be discontinued if
the mother is treated on study.

- Bevacizumab has been associated with the development of treatment-related
hypertension that can become urgent or emergent. Evidence of uncontrolled
hypertension in patients prior to study enrollment will preclude enrollment onto this
study until blood pressure is controlled. Uncontrolled hypertension is defined as the
presence of systolic blood pressure greater or equal to 150 mmHg or diastolic blood
pressure greater or equal to 100 mmHg measured on two separate occasions.

- Patients with known HIV or with solid organ transplant (because of potential
additional risk for cytopenias).