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Candidate Gene Variants and Childhood/Adolescent Non-Hodgkin Lymphoma: A Preliminary Investigation


N/A
N/A
20 Years
Open (Enrolling)
Both
Lymphoma

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Trial Information

Candidate Gene Variants and Childhood/Adolescent Non-Hodgkin Lymphoma: A Preliminary Investigation


OBJECTIVES:

- To conduct a preliminary investigation of the effects of loci strongly and consistently
associated in prior genome-wide association studies (GWAS) and validation studies of
childhood/adolescent acute lymphoblastic leukemia (ALL), adult non-Hodgkin lymphoma
(NHL), autoimmune diseases, and atopic diseases on the risk of NHL (lymphoblastic and
Burkitt lymphomas) in children and adolescents.

OUTLINE: DNA samples are analyzed by single nucleotide polymorphism and genotyped by
fluorogenic polymerase chain reaction (PCR)-based allelic discrimination (Taqman) assays
using the ABI Prism 7900HT reverse transcriptase (RT)-PCR system.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Slides and/or other available specimens from patients diagnosed with lymphoblastic
lymphoma (LL) or Burkitt lymphoma ( BL) enrolled on the Children Oncology Group (COG)
protocols 5961, A5971, and ANHL01P1 collected at the time of diagnosis and currently
housed at the Biopathology Center at Nationwide Children's Hospital

- Samples from non-Hispanic white patients

- DNA samples from 384 healthy, anonymous, non-Hispanic white blood donors used as
controls

PATIENT CHARACTERISTICS:

- See Disease Characteristics

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Gene variants associated with childhood/adolescent NHL (lymphoblastic and Burkitt lymphomas)

Principal Investigator

Amy Linabery, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Masonic Cancer Center, University of Minnesota

Authority:

United States: Federal Government

Study ID:

CDR0000735336

NCT ID:

NCT01623856

Start Date:

June 2012

Completion Date:

Related Keywords:

  • Lymphoma
  • childhood lymphoblastic lymphoma
  • childhood Burkitt lymphoma
  • Lymphoma
  • Lymphoma, Non-Hodgkin

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