Candidate Gene Variants and Childhood/Adolescent Non-Hodgkin Lymphoma: A Preliminary Investigation
- To conduct a preliminary investigation of the effects of loci strongly and consistently
associated in prior genome-wide association studies (GWAS) and validation studies of
childhood/adolescent acute lymphoblastic leukemia (ALL), adult non-Hodgkin lymphoma
(NHL), autoimmune diseases, and atopic diseases on the risk of NHL (lymphoblastic and
Burkitt lymphomas) in children and adolescents.
OUTLINE: DNA samples are analyzed by single nucleotide polymorphism and genotyped by
fluorogenic polymerase chain reaction (PCR)-based allelic discrimination (Taqman) assays
using the ABI Prism 7900HT reverse transcriptase (RT)-PCR system.
Gene variants associated with childhood/adolescent NHL (lymphoblastic and Burkitt lymphomas)
Amy Linabery, PhD
Masonic Cancer Center, University of Minnesota
United States: Federal Government