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Contribution of 18FDG PET-Scan in Tumour Volume Determination in Patients Operated of Breast Cancer

18 Years
Not Enrolling
Infiltrating Ductal Carcinoma

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Trial Information

Contribution of 18FDG PET-Scan in Tumour Volume Determination in Patients Operated of Breast Cancer

The use of positron emission tomography (PET) in determination of functional tumour volume
may pose two major problems especially for the exact delineation of tumour contours:

- Respiratory movements, when the tumour is thoracic, may induce an overestimation

- The PET's low spatial resolution, linked to the emission of photons

The usual method to define tumour contours result of three types of delineation usually
used: the visual contouring, the segmentation based on an activity threshold fixed, and the
segmentation with adaptive thresholding.

Inclusion Criteria:

- Invasive non-lobular breast cancer, histologically proven by biopsy

- Tumour T2 - T3 regardless of nodal status, stemming from a primary surgery, in whom
FDG-PET is performed for staging

- Age greater than or equal to 18 years

- Good condition: WHO lower 2.

- Women receiving effective contraception throughout the duration of treatment and 3
months after cessation of treatment,

- Patient has signed informed consent

Exclusion Criteria:

- Carcinoma other than breast ductal carcinoma.

- Patients for whom no target tumor is assessable.

- Patients for whom surgery first of their breast cancer is not indicated (tumor
spread, metastasis, general health, co-morbidities).

- Pregnant women, or likely to be during breastfeeding.

- Major protected (under supervision and under guardianship)

- Failure to submit to medical supervision of the study for reasons of geography,
social or psychological

- Incomplete tumor resection

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Principal Investigator

Pierre VERA, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Centre H.Becquerel


France: Institutional Ethical Committee

Study ID:

CHB 09.01



Start Date:

February 2010

Completion Date:

May 2012

Related Keywords:

  • Infiltrating Ductal Carcinoma
  • Positron-Emission Tomography
  • PET Scan
  • FDG
  • SUV
  • Invasive Breast cancer
  • Surgery compare
  • Tumor measurement
  • Breast Neoplasms
  • Carcinoma
  • Carcinoma, Ductal, Breast
  • Carcinoma, Ductal