Trial Information
Evaluation of Polymorphisms and Mutations in Genes Postulated to Alter the Efficacy of Gefitinib in Samples From E1302
OBJECTIVES:
- To evaluate the frequency of ATP-binding cassette, sub-family G (WHITE), member 2
(ABCG2), met proto-oncogene (hepatocyte growth factor receptor) (c-MET), and v-Ki-ras2
Kirsten rat sarcoma viral oncogene homolog (K-ras) polymorphisms or mutations in this
study population and the predictiveness of these polymorphisms on survival, time to
progression, response rate, and toxicities.
OUTLINE: Archived tumor tissue and peripheral blood mononuclear cells are analyzed for the
frequency of ABCG2, c-MET, and K-ras polymorphisms or mutations by polymerase chain reaction
(PCR). Results are then correlated with patients' clinical outcomes and toxicity.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Patients diagnosed with recurrent or metastatic head and neck cancer treated on
Eastern Cooperative Oncology Group (ECOG)-E1302 trial
- Patients treated with docetaxel with versus without gefitinib
- Existing paraffin blocks and peripheral blood mononuclear cells
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
The prevalence of c-MET, ABCG2, and K-ras polymorphisms or mutation status summarized by frequency and percentage for all samples
Safety Issue:
No
Principal Investigator
Jill Kolesar, PharmD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of Wisconsin, Madison
Authority:
Unspecified
Study ID:
CDR0000734898
NCT ID:
NCT01619618
Start Date:
May 2012
Completion Date:
Related Keywords:
- Head and Neck Cancer
- recurrent squamous cell carcinoma of the hypopharynx
- stage IV squamous cell carcinoma of the hypopharynx
- recurrent squamous cell carcinoma of the larynx
- stage IVA squamous cell carcinoma of the larynx
- stage IVB squamous cell carcinoma of the larynx
- stage IVC squamous cell carcinoma of the larynx
- recurrent squamous cell carcinoma of the lip and oral cavity
- stage IVA squamous cell carcinoma of the lip and oral cavity
- stage IVB squamous cell carcinoma of the lip and oral cavity
- stage IVC squamous cell carcinoma of the lip and oral cavity
- recurrent metastatic squamous neck cancer with occult primary
- recurrent squamous cell carcinoma of the nasopharynx
- stage IV squamous cell carcinoma of the nasopharynx
- recurrent squamous cell carcinoma of the oropharynx
- stage IVA squamous cell carcinoma of the oropharynx
- stage IVB squamous cell carcinoma of the oropharynx
- stage IVC squamous cell carcinoma of the oropharynx
- recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage IVA squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage IVB squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage IVC squamous cell carcinoma of the paranasal sinus and nasal cavity
- recurrent salivary gland cancer
- stage IVA salivary gland cancer
- stage IVB salivary gland cancer
- stage IVC salivary gland cancer
- Head and Neck Neoplasms