Trial Information

Interventions to Increase Screening Utilization by Breast Cancer Survivors and Their High Risk Female Relatives: Using Cancer Surveillance and the Michigan Genomics Academic-Practice Partnership

The University of Michigan (UM) Schools of Nursing, Public Health, and Medicine, the
Michigan Department of Community Health (MDCH) and the Michigan Cancer Consortium (MCC)
propose a multidisciplinary academic/practice three-year project to increase appropriate
breast cancer screening utilization for young breast cancer survivors (YBCS), and their
cancer-free, female relatives at greatest risk for breast cancer (high-risk relatives). The
aims of this project are to: 1) identify and survey 3000 breast cancer survivors reported to
the Michigan Cancer Surveillance Program who were diagnosed between the ages of 25-45 years
regarding their breast cancer screening utilization; 2) identify and survey YBCS' high-risk
relatives regarding their breast cancer screening utilization; and 3) implement two versions
(targeted vs. enhanced tailored) of an evidence-based intervention recommended by the Guide
to Community Preventive Services to increase breast cancer screening. Aim 1, will be
accomplished in year 1 by MDCH, UM and MCSP. Following approval by appropriate review boards
(MDCH, UM, and MCSP), reporting facilities and physicians of record, 3000 YBCS will be
mailed a request to participate in the project and a baseline survey. The baseline survey
will obtain information on the YBCS's: a) willingness to participate; b) current breast
cancer screening utilization; c) perceived barriers and facilitators to screening and other
outcomes related to breast cancer screening; d) identification of high-risk relatives to
participate in the study and interest in serving as an advocate for their high-risk
relatives to participate. Aim 2, will be accomplished in year 2 by the UM and MDCH. Based on
the information provided by YBCS, the MDCH will identify up to two high-risk relatives per
YBCS. UM and MDCH will mail YBCS who agree to participate in the study baseline surveys to
distribute to their selected high-risk relatives. The baseline survey to high-risk relatives
will obtain information on their: a) willingness to participate in the project; b) current
breast cancer screening utilization; and c) perceived barriers and facilitators to screening
and other outcomes related to breast cancer screening. Aim 3, will be accomplished by UM and
MDCH. YBCS and their high-risk relatives will be randomized (as a family unit) to receive
two versions of a small media, evidence-based intervention aiming to increase appropriate
utilization of breast cancer screening services and other outcomes. In year 2-3, 9 months
after YBCS and high-risk female relatives receive the intervention, UM will mail a follow-up
survey to YBCS and their high-risk relatives to evaluate the effectiveness of each
intervention version on: a) breast cancer screening utilization; b) perceived barriers and
facilitators to screening; c) self-efficacy in utilizing screening services; d) family
support related to screening; e) knowledge of the genetics of breast cancer and personal
risk factors; and f) satisfaction with the intervention. The State of Michigan is considered
a national leader in cancer prevention, control, and public health genomics. Key partners
have significant prior experience in conducting studies with cancer survivors and their
high-risk relatives. This project would greatly enhance state efforts in cancer prevention
and control.