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Tissue Microarray Studies of the 12q13-q14 Amplicon in Alveolar Rhabdomyosarcoma


N/A
N/A
21 Years
Open (Enrolling)
Both
Sarcoma

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Trial Information

Tissue Microarray Studies of the 12q13-q14 Amplicon in Alveolar Rhabdomyosarcoma


OBJECTIVES:

- To investigate (in two stages) which proteins are overexpressed in association with
12q13-q14 amplification by applying fluorescence in situ hybridization (FISH) and
immunohistochemical (IHC) assays to a panel of alveolar rhabdomyosarcomas (ARMS) cases
organized into tissue microarrays.

OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed for 12q13-q14
frequency and protein overexpression by FISH and IHC.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Slides of the 2006 alveolar rhabdomyosarcoma (ARMS) tissue microarray (TMA) and the
2009 ARMS/anaplastic embryonal rhabdomyosarcoma (ERMS) TMA

- PAX3-FOXO1-positive tumors

- PAX7-FOXO1-positive tumors

- Fusion-negative tumors

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Relationship of amplification and fusion status using Fisher's exact test and Freeman-Halton test

Safety Issue:

No

Principal Investigator

Frederick Barr, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

NCI - Laboratory of Pathology

Authority:

United States: Federal Government

Study ID:

CDR0000734381

NCT ID:

NCT01609803

Start Date:

June 2012

Completion Date:

Related Keywords:

  • Sarcoma
  • alveolar childhood rhabdomyosarcoma
  • embryonal childhood rhabdomyosarcoma
  • previously treated childhood rhabdomyosarcoma
  • previously untreated childhood rhabdomyosarcoma
  • recurrent childhood rhabdomyosarcoma
  • Rhabdomyosarcoma
  • Rhabdomyosarcoma, Alveolar
  • Sarcoma

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