Use of 11C Acetate Imaging for Improved Prediction of the Effectiveness of Salvage Pelvic Radiation Post Prostatectomy: A Pilot Study
If you decide to participate in the study and are eligible, you will undergo a single [11C]
acetate PET scan. This scan is designed to detect small amounts of your tumor that were not
detected by the CT scan or the bone scan. On the day of the scan, you will fast for at least
four hours prior to being given the tracer injection by vein. You will then be scanned in
the PET scanner. The entire procedure will take approximately 2 hours.
The investigators would like to keep track of your medical condition after you have
completed your scan. The investigators would like to do this by looking up information in
your medical record during the year following the scan to see how you are doing. Checking
your condition helps us understand whether the [11C] acetate PET scan will be helpful to
other patients in the future.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Sensitivity of 11C Acetate PET
Preliminarily demonstrate that the 11C acetate PET imaging of subjects who have experienced PSA relapse after prostatectomy for prostate cancer is more sensitive than currently available imaging techniques. Enrolled participants will have no evidence of recurrent disease on gold-standard imaging with CT abdomen/pelvis and 99mTc MDP bone scan (approximate sensitivity of 0%). The primary outcome is evidence of residual/recurrent disease as demonstrated by 11C acetate PET uptake outside of the prostatectomy bed.
Umar Mahmood, MD, PhD
Massachusetts General Hospital
United States: Institutional Review Board
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