Inclusion Criteria:

- Patients ages 2 years to 21 years.

- Patients with NF-1 being followed in the Neurofibromatosis Clinic.

- Patients have had MRI imaging in the 24 months prior to enrollment on the study.

- Patients may have known concurrent malignancies such as plexiform neurofibroma.

- Patients and/or parents/legal guardians must have signed an informed consent and
assent when applicable.

Exclusion Criteria:

- Patients who have had prior tumor-directed therapy (including chemotherapy and/or
radiation)

- Patients with a prior or current diagnosis of a malignant peripheral nerve sheath
tumor.

- Patients who are considered too ill to participate as determined by their treating
physician

- Patients who are pregnant or lactating