Weekly Cisplatin or Weekly Liposome Paclitaxel Concurrent Radiation Therapy in Treating Elderly People With Cervical Cancer
Concurrent radiotherapy is the standard treatment of inoperable cervical cancer .Due to the
physical conditions, elderly patients usually associated with medical complications, so
generally just receive radiotherapy alone. Recently, some retrospective studies have shown
that the impact of chemotherapy did not cause an increase in the complication rate among
elderly patients as compared to younger patients with cervical cancer, and may improve the
survival when concurrent with radiotherapy. Cisplatin and paclitaxel are two effective drug
in treating cervical cancer, but whether they are safe enough for elderly when concurrent
with radiotherapy, there are no clearly reports. In this study ,we replace the conventional
dose chemotherapy with weekly cisplatin or lipsome paclitaxel , to compare the efficiency
and safety of weekly cisplatin / liposome paclitaxel concurrent chemoradiotherapy and
radiotherapy alone in the treatment of cervical cancer in elderly patients.
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Objective Response Rate
Objective Response Rate: Complete response (CR)+ Partial response (PR) rates base on RECIST evaluation system.
1 month after the treatment completed
No
Chen M W, M.D
Study Director
Affiliated Hospital of Medical College of Xi'an Jiaotong University
China: Ministry of Health
GCR-02
NCT01594099
April 2012
March 2014
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