Consortium for the Sharing of Germ Line DNA and Tissue From Subjects With Mesothelioma
Mesothelioma is a cancer that develops from serosal surfaces usually in response to prior
asbestos exposure. A history of asbestos exposure can be elicited in more than 80% of
mesothelioma victims. However, asbestos exposure alone is not sufficient to cause the
development of mesothelioma. Nearly 27 million individuals in the US, were exposed to
asbestos in the work place between 1940 and 1979 but just 3,000 new cases of mesothelioma
are diagnosed each year. Therefore, the investigators hypothesis is that genetic variation
in addition to asbestos exposure, and host factors contribute to the development of
mesothelioma. It is estimated, based on the investigators preliminary studies, that a
population in excess of 1,000 subjects with mesothelioma is required to perform a valid
Therefore a multicenter approach is necessary to collect data and DNA on sufficient numbers
with mesothelioma to adequately evaluate genetic risk. It is the aim of this proposal to
develop a consortium of mesothelioma investigators to share phenotypic data and DNA samples
and to perform genome wide association scanning (GWAS).
Observational Model: Case-Only, Time Perspective: Cross-Sectional
Creation of a consortium of investigators (7 sites) for collection of blood for germline DNA and demographic information from 1000 mesothelioma subjects.
Demographic variables that will be collected include; date of birth, gender, age at first exposure to asbestos, type of exposure (occupational or bystander), family health history, personal past medical history, smoking history, age at diagnosis, latency, tumor location and cell type.
Participants will be seen on one occasion lasting 30-60 min to draw blood and elicit demographic information. It will require up to 2 years to enroll 1000 subjects with mesothelioma from the various sites.
Jill Ohar, MD
Wake Forest University
United States: Institutional Review Board
GTS 36076 MARF
|Johns Hopkins University||Baltimore, Maryland 21205|
|Memorial Sloan Kettering Cancer Center||New York, New York 10021|
|Mayo Clinic||Rochester, Minnesota 55905|
|Mount Sinai School of Medicine||New York, New York 10029|
|University of Pennsylvania||Philadelphia, Pennsylvania 19104|
|New York University School of Medicine||New York, New York 10016|
|Wake Forest University Health Sciences||Winston-Salem, North Carolina 27157|