Trial Information

Consortium for the Sharing of Germ Line DNA and Tissue From Subjects With Mesothelioma

Mesothelioma is a cancer that develops from serosal surfaces usually in response to prior
asbestos exposure. A history of asbestos exposure can be elicited in more than 80% of
mesothelioma victims. However, asbestos exposure alone is not sufficient to cause the
development of mesothelioma. Nearly 27 million individuals in the US, were exposed to
asbestos in the work place between 1940 and 1979 but just 3,000 new cases of mesothelioma
are diagnosed each year. Therefore, the investigators hypothesis is that genetic variation
in addition to asbestos exposure, and host factors contribute to the development of
mesothelioma. It is estimated, based on the investigators preliminary studies, that a
population in excess of 1,000 subjects with mesothelioma is required to perform a valid
GWAS.

Therefore a multicenter approach is necessary to collect data and DNA on sufficient numbers
with mesothelioma to adequately evaluate genetic risk. It is the aim of this proposal to
develop a consortium of mesothelioma investigators to share phenotypic data and DNA samples
and to perform genome wide association scanning (GWAS).