Trial Information
Radiogenomic Assessment in NSCLC: Correlation Between Multiparametric Imaging Biomarkers and Genetic Biomarkers
To evaluate relationships between multiparametric imaging biomarkers(MRI, PET/CT) and
genetic analysis in NSCLC patients
Inclusion Criteria:
- Suspected lung cancer on chest chest CT or histologically proven NSCLC
- Participant is being considered for the conventional/neoadjuvant/targeted
chemotherapy or surgery
- At least one measurable primary or other intrathoracic lesion >= 2cm, according to
RECIST
- Performance status of 0 to 2 on the ECOG scale
- Age 20 years or older
- Able to tolerable PET/CT and MRI imaging required by protocol
- Able to undergo percutaneous needle biopsy before and after chemotherapy
- Able to give study-specific informed consent
Exclusion Criteria:
- Poorly controlled diabetes
- Contraindication for MRI contrast agent
Type of Study:
Observational
Study Design:
Observational Model: Case-Only, Time Perspective: Prospective
Outcome Measure:
functional and genetic profile of lung cancer
Outcome Description:
following parameters will be calculated using these values:
Metabolic parameters on FDG-PET
Perfusion parameters on DCE-MRI
Diffusion parameters on DWI
Mutation analysis of lung cancer tissue
Outcome Time Frame:
two years
Safety Issue:
No
Principal Investigator
Ho Yun Lee, Dr
Investigator Role:
Principal Investigator
Investigator Affiliation:
Samsung Medical Center
Authority:
South Korea: Institutional Review Board
Study ID:
2012-03-068
NCT ID:
NCT01585545
Start Date:
May 2012
Completion Date:
April 2014
Related Keywords:
- Lung Cancer
- MRI
- PET CT
- mutational analysis
- Lung Neoplasms