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Radiogenomic Assessment in NSCLC: Correlation Between Multiparametric Imaging Biomarkers and Genetic Biomarkers


N/A
20 Years
N/A
Not Enrolling
Both
Lung Cancer

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Trial Information

Radiogenomic Assessment in NSCLC: Correlation Between Multiparametric Imaging Biomarkers and Genetic Biomarkers


To evaluate relationships between multiparametric imaging biomarkers(MRI, PET/CT) and
genetic analysis in NSCLC patients


Inclusion Criteria:



- Suspected lung cancer on chest chest CT or histologically proven NSCLC

- Participant is being considered for the conventional/neoadjuvant/targeted
chemotherapy or surgery

- At least one measurable primary or other intrathoracic lesion >= 2cm, according to
RECIST

- Performance status of 0 to 2 on the ECOG scale

- Age 20 years or older

- Able to tolerable PET/CT and MRI imaging required by protocol

- Able to undergo percutaneous needle biopsy before and after chemotherapy

- Able to give study-specific informed consent

Exclusion Criteria:

- Poorly controlled diabetes

- Contraindication for MRI contrast agent

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

functional and genetic profile of lung cancer

Outcome Description:

following parameters will be calculated using these values: Metabolic parameters on FDG-PET Perfusion parameters on DCE-MRI Diffusion parameters on DWI Mutation analysis of lung cancer tissue

Outcome Time Frame:

two years

Safety Issue:

No

Principal Investigator

Ho Yun Lee, Dr

Investigator Role:

Principal Investigator

Investigator Affiliation:

Samsung Medical Center

Authority:

South Korea: Institutional Review Board

Study ID:

2012-03-068

NCT ID:

NCT01585545

Start Date:

May 2012

Completion Date:

April 2014

Related Keywords:

  • Lung Cancer
  • MRI
  • PET CT
  • mutational analysis
  • Lung Neoplasms

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