Clinical, Biochemical, Dosimetric and Functional Respiratory Predictors of Radiation Pneumonitis in Locally Advanced Lung Cancer (Stages IIIa and IIIb) Treated With Chemotherapy and Radiotherapy
To evaluate the effect of chemotherapy and thoracic radiotherapy on pulmonary function and
identify predictors of radiation pneumonitis in locally advanced lung cancer [stages IIIA
Respiratory function tests may predict the development of radiation pneumonitis in patients
with locally advanced lung cancer who receive radical treatment with chemoradiation.
Methods Prospective cohort study with patients with locally advanced lung cancer of the Lung
Cancer Clinic of the National Cancer Institute [INCAN]. Patients will receive weekly
paclitaxel 50 mg and carboplatin AUC 2 with concomitant radiotherapy 44-63 Gy (22-33
fractions). Followup of lung function tests at baseline, during treatment with radiotherapy
and will be carried out on 4 more occasions.
Observational Model: Cohort, Time Perspective: Prospective
Evaluate pulmonary function after chemoradiation treatment in locally advanced NSCLC patients.
January 2012 to December 2014
Oscar Arrieta, MD
Instituto de Cancerología
Mexico: Ethics Committee