Inclusion Criteria:

- The patient must have given his/her informed and signed consent

- The patient must be insured or beneficiary of a health insurance plan

- Patient with adenocarcinoma-type colorectal cancer:

- stage III at diagnosis, surgical resection of the primary tumor proposed.

- stage IV at diagnosis, surgical resection of the primary tumor and possibly of
metastases proposed.

- Stage IV who have already undergone surgical excision of the primary tumor, and for
whom metastasectomy is now proposed.

Exclusion Criteria:

- The patient is participating in another study

- The patient is in an exclusion period determined by a previous study

- The patient is under judicial protection, under tutorship or curatorship

- The patient refuses to sign the consent

- It is impossible to correctly inform the patient

- Patients for whom surgical resection of the primary tumor is not considered as an
option

- PStage IV at diagnosis, but metastasectomy is not considered as an option

- Patients with positive HIV, Hepatitis B or Hepatitis C serology