Pilot Study: Dynamic Contrast-enhanced Magnetic Resonance Imaging(DCE-MRI)for Assessing Tumor Vascularity and Permeability in Soft Tissue Sarcoma Treated With Preoperative Radiotherapy Followed by Surgical Resection
All patients have biopsy proven soft tissue sarcoma and undergo preoperative radiotherapy.
Dynamic contrast-enhancing MRI T1-weight DCE-MRI will cover the whole tumor and involved
lymph nodes if indicated. DCE-MRI is obtained before radiation starts and 4 weeks after RT
completes. Blood volume images are estimated by using general Toft model, by which the blood
flow was corrected for vascular permeability and perfusion. These images are geometrically
co-registered with post-Gd T1-weighted MR images and pre-op RT routine MRI images are fused
with the treatment planning CT.
Routine and DCE-MRI will be evaluated in each patient to determine the gross tumor volume.
The quantitative parameters are determined on DCE-MRI for quantitative parameters in blood
flow and permeability in the region of interest. Dynamic images are converted into color
maps reflecting Ktrans, kep, Ve, and mean value of each parameter.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening
Feasibility of DCE-MRI (Dynamic contrast-enhancing) in adult soft tissue sarcoma
Ying Hitchcock, MD
Huntsman Cancer Institute
United States: Institutional Review Board
|Huntsman Cancer Institute||Salt Lake City, Utah 84112|