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Chemotherapy Resistance and Sensitivity Testing in Lung Tumors


N/A
18 Years
N/A
Open (Enrolling)
Both
Lung Cancer

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Trial Information

Chemotherapy Resistance and Sensitivity Testing in Lung Tumors


The chemosensitivity assay will be performed on tissue obtained during the diagnostic fine
needle aspiration, core biopsy, or excisional biopsy of the lung lesion. Cancer cells (Bulk
of tumor) and Cancer Stem Cells (CSCs) will be isolated and expanded in the laboratory.

The drug screening assay will be used to evaluate the response of the CSCs and of the cancer
cells to the various chemotherapy regimens.


Inclusion Criteria:



- suspected or confirmed diagnosis of lung cancer

- undergoing a fine needle aspiration, core biopsy, or excisional biopsy for
diagnosis.

- Chemotherapy must be clinically indicated for treatment of the patient's qualifying
disease

- Patient must be at least 18 years of age

- Patient must have signed an IRB approved informed consent form for the data
collection study prior to entry of data into the enrollment form in the database.

Exclusion Criteria:

- Patient pathology shows benign pathology for sample submitted

- Patient is not indicated to receive chemotherapy for their disease

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Tumor size

Outcome Description:

Tumor response will be evaluated (progression/regression) by CT scan at 3 months from therapy start. Clinical response to chemotherapy of lung cancer tumor cells versus lung cancer stem cells to standard of care chemo drugs will be evaluated and correlated to predicted drug by ex vivo assay.

Outcome Time Frame:

3 months

Safety Issue:

No

Principal Investigator

Pier P. Claudio, M.D., Ph. D

Investigator Role:

Principal Investigator

Investigator Affiliation:

Marshall University School of Medicine

Authority:

United States: Institutional Review Board

Study ID:

246601-1

NCT ID:

NCT01570855

Start Date:

October 2011

Completion Date:

June 2014

Related Keywords:

  • Lung Cancer
  • Lung cancer
  • chemosensitivity
  • Lung Neoplasms

Name

Location

Cabell Huntington HospitalHuntington, West Virginia  25701