Chemotherapy Resistance and Sensitivity Testing in Lung Tumors
The chemosensitivity assay will be performed on tissue obtained during the diagnostic fine
needle aspiration, core biopsy, or excisional biopsy of the lung lesion. Cancer cells (Bulk
of tumor) and Cancer Stem Cells (CSCs) will be isolated and expanded in the laboratory.
The drug screening assay will be used to evaluate the response of the CSCs and of the cancer
cells to the various chemotherapy regimens.
Observational Model: Cohort, Time Perspective: Prospective
Tumor response will be evaluated (progression/regression) by CT scan at 3 months from therapy start. Clinical response to chemotherapy of lung cancer tumor cells versus lung cancer stem cells to standard of care chemo drugs will be evaluated and correlated to predicted drug by ex vivo assay.
Pier P. Claudio, M.D., Ph. D
Marshall University School of Medicine
United States: Institutional Review Board
|Cabell Huntington Hospital||Huntington, West Virginia 25701|