Influence of Meal Timing on Glucose Metabolism and Hyperandrogenism in Lean Women With Polycystic Ovary Syndrome
Insulin resistance and hyperinsulinemia plays a pivotal role in the pathogenesis of
polycystic ovary syndrome (PCOS). Hyperinsulinemia stimulates ovarian cytochrome P450c17
alpha activity, in obese and nonobese women with PCOS, thereby increasing serum levels of
17-alpha-hydroxyprogesterone, androgens concentrations, decreasing SHBG and promoting the
clinical features of hyperandrogenism.
In women with PCOS, weight loss improves insulin resistance and hyperandrogenism, resulting
in improvement of clinical symptoms. Since lean women with PCOS do not have the option of
weight loss, it is important to know weather diet composition and meal timing distribution
may influence glucose metabolism and hyperandrogenism.
We hypothesized that a timing pattern of increased nutrient intake of protein and
carbohydrates in the morning, with decreased caloric intake at night would improve insulin
sensitivity and hyperandrogenism in lean women with PCOS.
Objective:The objective of this study is to investigate the effects of two isocaloric diets
with different meal timing distribution on insulin resistance and hyperandrogenism in lean
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Androgens will be evaluate at baseline and after one of two isocaloric diet that differe in meal timing distribution
Daniela Jakubowicz, MD
Diabetes Unit E. Wolfson Medical Center Tel Aviv University
Israel: Ethics Commission