The Effect Of Cabergoline On Follicular Microenvironment Profile In Patients With High Risk Of Ohss
23 Years
35 Years
Female
Polycystic Ovarian Syndrome, Ovarian Hyperstimulation Syndrome
Trial Information
The Effect Of Cabergoline On Follicular Microenvironment Profile In Patients With High Risk Of Ohss
Dopamine agonists have been proposed as a prophylactic treatment for OHSS in women with high
risk of OHSS, however the possible mechanism of action has not been clearly known. In
experimental studies, inhibition of vascular endothelial growth factor based pathway was
proposed as a possible action of mechanism of dopamine agonists. However the role hepatocyte
growth factor (HGF), insulin like growth factor-I (IGF-I), inhibin B and antimullerian
hormone (AMH) on cabergoline action in OHSS prevention has not been known.
Inclusion Criteria:
- Development of more than 14 leading follicles larger than 10 mm and serum estradiol
more than 3000 pg/ml at the end of ovulation induction with long luteal ovulation
induction protocol.
- Having the criteria of PCOS
Exclusion Criteria:
- Not having the inclusion criteria.
Type of Study:
Interventional
Study Design:
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Outcome Measure:
Concentrations of follicular fluid AMH
Outcome Time Frame:
1 year
Safety Issue:
No
Principal Investigator
Emine Seda Guvendag Guven, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Rize University, Faculty of Medicine
Authority:
Turkey: Ethics Committee
Study ID:
ESG1
NCT ID:
NCT01569256
Start Date:
March 2008
Completion Date:
March 2009
Related Keywords:
- Polycystic Ovarian Syndrome
- Ovarian Hyperstimulation Syndrome
- Polycystic Ovary Syndrome
- Ovarian Hyperstimulation Syndrome
Name | Location |
|---|
