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Stem Cells And The Origins Of Barrett's Esophagus:Identification Of Novel Biomarkers And Gene Signatures In Barrett's Esophagus


N/A
18 Years
N/A
Open (Enrolling)
Both
Barrett's Esophagus

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Trial Information

Stem Cells And The Origins Of Barrett's Esophagus:Identification Of Novel Biomarkers And Gene Signatures In Barrett's Esophagus


This Project is designed to identify biologically-based and clinically-useful biomarkers of
tissue at risk for neoplastic progression as well as of response to ablation therapy. These
results will result in improved risk stratification in BE and better targeting of resources
for patients who are candidates for ablative therapy, while simultaneously providing key
information regarding the origins of Barrett's esophagus.


Inclusion Criteria:



- Barrett's esophagus with high grade dysplasia or intramucosal (early)
adenocarcinoma.

- BE length ≥ 2 cm and ≤ 8 cm.

- Able to return every 3 months for one year after ablation

Exclusion Criteria:

- Patients who are unable to be compliant with follow-up endoscopies

- patients who cannot tolerate Proton Pump inhibitors

- pre-existing esophageal strictures

- pregnant or nursing women

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Response to therapy

Outcome Description:

evaulation will be made at 3 month intervals for one year post ablation

Outcome Time Frame:

one year post ablation

Safety Issue:

No

Principal Investigator

Kenneth K Wang, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Mayo Clinic

Authority:

United States: Institutional Review Board

Study ID:

11-006510

NCT ID:

NCT01568723

Start Date:

January 2012

Completion Date:

August 2018

Related Keywords:

  • Barrett's Esophagus
  • Barrett's esophagus
  • high grade dysplasia
  • ablation
  • radiofrequency ablation
  • esophageal cancer
  • Barrett Esophagus

Name

Location

Columbia UniversityNew York, New York  10032-3784
University of Pennsylvania Perelman School of MedicinePhiladelphia, Pennsylvania  19104-4311