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Potentially Actionable Mutations in Archived Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS)


N/A
N/A
30 Years
Open (Enrolling)
Both
Chordoma, Desmoid Tumor, Sarcoma

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Trial Information

Potentially Actionable Mutations in Archived Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS)


OBJECTIVES:

- To determine the frequency with which actionable mutations are found in archived
non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) tumor specimens using mass
spectrometry (MS) analysis of tumor-derived deoxyribonucleic acid (DNA).

OUTLINE: Archived DNA tissue samples are analyzed for frequency of genetic mutations,
including single nucleotide polymorphisms (SNPs), single nucleotide variants (SNVs), and
small deletions and/or insertions, by polymerase chain reaction (PCR) and mass spectometry
(Sequenom MassARRAY). Results are then analyzed to determine whether specific mutations
correlate with patient or disease features such as tumor stage, histological grade, or
outcome.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Archived non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) tumor-derived DNA

- Synovial sarcoma, malignant peripheral nerve sheath tumor (MPNST), soft tissue
sarcoma not otherwise specified (NOS), or other less common pediatric NRSTS

- Formalin-fixed, paraffin-embedded (FFPE) tissue from patients enrolled on:

- COG-D9902 Soft Tissue Sarcoma (STS) Biology and Banking Protocol

- COG-ARST0332 A Risk-Based Treatment for Pediatric NRSTS Study

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Frequency of individual mutated genes in patients with NRSTS

Safety Issue:

No

Principal Investigator

Steve Skapek, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Texas Southwestern Medical Center at Dallas

Authority:

United States: Federal Government

Study ID:

CDR0000729355

NCT ID:

NCT01567046

Start Date:

March 2012

Completion Date:

Related Keywords:

  • Chordoma
  • Desmoid Tumor
  • Sarcoma
  • childhood alveolar soft-part sarcoma
  • childhood angiosarcoma
  • childhood epithelioid sarcoma
  • childhood fibrosarcoma
  • childhood leiomyosarcoma
  • childhood liposarcoma
  • childhood neurofibrosarcoma
  • childhood synovial sarcoma
  • metastatic childhood soft tissue sarcoma
  • nonmetastatic childhood soft tissue sarcoma
  • recurrent childhood soft tissue sarcoma
  • chordoma
  • childhood desmoplastic small round cell tumor
  • desmoid tumor
  • childhood malignant mesenchymoma
  • Chordoma
  • Fibromatosis, Aggressive
  • Sarcoma

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