A Multicenter, Randomised, Double-blinded, Placebo-controlled Trial Comparing the Efficacy and Safety of Intravenous Parecoxib Sodium on Morphine Patient-controlled Epidural Analgesia After Gynecologic Surgery
Researches have showed that the use of epidural and spinal block resulted in significant
reduction in morbidity and mortality after surgery. Moreover, appropriate pain management
results in better outcomes. Opioids therapy is recommended as the first choice medication
for the management of postoperative pain but is associated with a number of undesirable
adverse effects. A multimodal therapy for providing postoperative analgesia has advantages
over the use of opioids alone. The use of NSAIDs and opioids together often improves
analgesia and reduces the need for opioids in the postoperative period. Often, the
combination of COX-2 inhibitors with epidural analgesia is preferred. With epidural
analgesia, addition of COX-2 inhibitors may improve the analgesia and decrease the
undesirable side effects.
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
morphine-sparing effect of parecoxib
The primary end-point of this study was to quantify the morphine-sparing effect of a multimodal approach containing parecoxib compared with the standard PCEA approach in patients undergoing abdominal hysterectomy.
within 48 h after skin closure
No
Wenqi Huang, postgraduate
Study Chair
The First Affliated Hospital, Sun Yet-Sen University
China: Ethics Committee
PCEA
NCT01566669
June 2009
May 2010
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