Inclusion Criteria:

- Histologically or cytologically confirmed Lung adenocarcinoma

- Wld-type EGFR

- Stage IIIB/IV

- Failure to prior chemotherapy

- Life expectancy of more than 3 months

- Tissue sample desired for genomic study

- Age ≥ 18 years

- Performance status (WHO) < 3

- Adequate bone marrow function (absolute neutrophil count > 1000/mm^3, platelet count
> 100000/mm^3, hemoglobin > 9gr/mm^3)

- Adequate liver (bilirubin < 1.5 times upper limit of normal and SGOT/SGPT < 2 times
upper limit of normal) and renal function (creatinine < 2mg/dl)

- Presence of two-dimensional measurable disease. The measurable disease should not
have been irradiated

- Informed consent

Exclusion Criteria:

- Have previously received pemetrexed or TKIs

- Other concurrent uncontrolled illness