Inclusion Criteria:

- Patient age (18 years)

- Benign giant cell tumor of the bone histologically confirmed after biopsy

- Non-metastatic tumor

- The first surgical treatment of the tumor

- Indication of conservative treatment with curettage, filling asked by the surgeon
investigator

- Written consent of the patient

Exclusion Criteria:

- Minor patient

- Location of a pulmonary TCG

- Surgical indication of prior or immediately en bloc resection

- Need for treatment with an aminoglycoside

- Against-indication for zoledronic acid: pregnancy, lactation, known hypersensitivity
to this drug or another bisphosphonate, severe renal impairment or a previous kidney
failure, severe bradycardia or conduction disturbance on ECG.

- Dental Problems in progress, including an infection of the teeth or jaw underlying
(mandible and maxilla), dental trauma or recent diagnosis or history of
osteo-necrosis of the jaw (ONJ)​​, or exposure of the OSE or delayed healing after
dental procedures.

- Dental or jaw bone recent (within 6 weeks) or planned (extractions, implants, ...).