Inclusion Criteria:

- Malignant melanoma (including melanoma of unknown primary site, recurrent and
pretreated systemic melanoma and/or melanoma with parenchymal CNS metastases) with
leptomeningeal metastasis as demonstrated by a positive CSF (cerebrospinal liquor)
cytology AND/OR by the presence of characteristic signs and symptoms of
leptomeningeal metastasis supported by an MRI scan indicating the presence of
meningeal tumour

- CSF flow abnormalities must be excluded

- Males or females ≥ 18 years of age

- Karnofsky Performance Status > 50%

- Adequate organ function (adequate bone marrow reserve, adequate liver function,
adequate renal function. adequate blood clotting)

Exclusion Criteria:

- Unresected parenchymal brain metastases with a diameter > 3 cm

- Prior non melanoma malignancy (unless adequately treated carcinoma in situ of the
cervix or non melanoma skin cancer)

- Prior intrathecal chemotherapy

- Prior treatment with systemic cytarabine or nitrosureas

- The patient ist pregnant or breast feeding

- Severe, active co-morbidities