Inclusion Criteria:

- Histologically proven CD40 expressing solid tumours or diffuse large B-cell
non-Hodgkin‟s lymphoma refractory to conventional treatment, or for which no
conventional therapy exists.

- Written informed consent and the ability of the patient to co-operate with treatment
and follow up must be ensured and documented.

- Age greater than 18 years.

- Life expectancy of at least 12 weeks.

- World Health Organisation (WHO) performance status of 0-1 (Appendix 1).

- Haematological and biochemical indices (These measurements must be performed within
one week prior to the patient going on study.)

- Haemoglobin (Hb) ≥ 9.0 g/dl

- Neutrophils ≥ 1 x 10^9/L

- Total Lymphocyte count ≥ 0.5 x 10^9/L

- Platelets (Plts) ≥ 75 x 10^9/L

- The following baseline liver function tests :

- Serum bilirubin ≤ 1.5 x upper limit of normal (ULN)

- Alanine amino-transferase (ALT) and/or aspartate amino-transferase (AST) ≤
3 x ULN unless due to tumour in which case up to 5 x ULN is permissible

- The following baseline renal function test:

- calculated creatinine clearance ≥ 40 mL/min (uncorrected value) or isotope
clearance measurement ≥ 40mL/min

- Female patients of child-bearing potential are eligible, provided they have a
negative serum or urine pregnancy test prior to enrolment and agree to use
appropriate medically approved contraception for four weeks prior to entering the
trial, during the trial and for six months afterwards.

- Male patients must agree to use appropriate medically approved contraception during
the trial and for six months afterwards.

Exclusion Criteria:

- CD40 negative tumours by immunohistochemistry.

- Radiotherapy (except for palliative reasons), endocrine therapy, immunotherapy or
chemotherapy during the previous four weeks (six weeks for nitrosoureas and
mitomycin-C) prior to treatment.

- All toxic manifestations of previous treatment must have resolved. Exceptions to this
are alopecia or certain Grade 1 toxicities which in the opinion of the Investigator
and Cancer Research UK should not exclude the patient.

- Pregnant and lactating women are excluded.

- Major thoracic and/or abdominal surgery in the preceding four weeks from which the
patient has not yet recovered.

- Patients with primary brain tumours or clinically apparent brain metastases.

- Patients who are high medical risks because of non-malignant systemic disease
including active uncontrolled infection.

- Patients with any other condition which in the Investigator‟s opinion would not make
the patient a good candidate for the clinical trial.

- Patients known to be serologically positive for Hepatitis B, Hepatitis C or Human
Immunodeficiency Virus (HIV).

- Long term immunosuppression or steroids (for more than one month)

- History of significant and serious allergy.

- Concurrent congestive heart failure or prior history of class III/ IV cardiac disease
(New York Heart Association [NYHA] - refer to Appendix 4)

- Patients with low grade or transformed non-Hodgkin‟s lymphoma.

- Prior treatment with murine monoclonal antibodies. (Prior treatment with chimeric or
fully human antibodies will not exclude a patient).

- A history of clinically significant autoimmune disease.

- Current malignancies at other sites, with the exception of adequately treated
cone-biopsied in situ carcinoma of the cervix uteri and basal or squamous cell
carcinoma of the skin. Cancer survivors, who have undergone potentially curative
therapy for a prior malignancy, have no evidence of that disease for five years and
are deemed at low risk for recurrence, are eligible for the study.