Inclusion Criteria:

- Newly diagnosed patients fulfilling the IMWG diagnostic criteria of PPCL

- Age > 18 years

- ECOG performance status of 0,1 or 2

- Life expectancy of at least 12 weeks

Exclusion Criteria:

- Myocardial infarction within 6 months prior to enrollment or uncontrolled angina

- Severe uncontrolled ventricular arrhythmias

- ECG evidence of acute ischemia or active conduction system abnormalities

- Female subjects either pregnant or breast-feeding

- Serious medical or psychiatric illness

- Total bilirubin greater than 2.0 mg/dL and/or SGOT or SGPT greater than two and a
half times normal (unless due to primary malignancy)

- History of severe hepatic dysfunction

- Active infections or HIV positivity

- Uncontrolled insulin-dependent diabetes mellitus

- Uncompensated major thyroid or adrenal dysfunction

- Hemodialysis or peritoneal dialysis

- Renal dysfunction (unless due to primary malignancy; in this case, enrollment at the
discretion of the principal investigator)

- ECOG performance status of 3 (unless due to primary malignancy; in this case,
enrollment at the discretion of the principal investigator)