Multicenter Prospective Randomized Phase III Trial Comparing Elective to Prophylactic Regional Lymph Node Irradiation for Thoracic Esophageal Cancer
Esophageal lymph node drainage area is rich, according to different sites, easy to
metastasis to different regions. For patient underwent concurrent chemoradiotherapy, how
reasonable design the clinical target volume of lymph node drainage area has always been
controversial, one is to irradiate positive lymph nodes only, the other is to irradiate the
easier involved lymph node area according to different sites, in order to contrast
advantages and disadvantages of the two kind of target area design，so the study was
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Local control rate/ Inside irrational field recurrence rate
Evaluation after treatment 3 months and two years in the tumor local control and key observation radiation fields inside and outside the tumor recurrence and lymph node metastatic rate. To guide the rational clinical target volume of lymph node of esophageal cancer underwnet concurrent chemoradiotherapy and to Prolong the survival time, improve the quality of life of the patients.
JINYI LANG, M.D.
The Second People's Hospital of Sichuan
China: Food and Drug Administration