Inclusion Criteria

- INCLUSION CRITERIA:

Multiple Myeloma Criteria:

Subjects with an indication for AHCT for the treatment of PCM as determined by the PI or
LAI.

- Subjects following induction treatment for PCM

- Subjects with recurrent or persistent evaluable disease who have not undergone AHCT
for the treatment of the PCM.

Other Eligibility Criteria:

Age greater than or equal to18 years and less than or equal to 75 years. In subjects
between 65 and 75 years of age, physiologic age and co-morbidity will be thoroughly
evaluated before enrolling.

Karnofsky performance status of 70% or greater (ECOG 0 or 1)

Ejection fraction (EF) by MUGA or 2-D echocardiogram within institution normal limits. In
case of low EF, the subject may remain eligible after a stress echocardiogram is performed
if the EF is more than 35% and if the increase in EF with stress is estimated at 10% or
more.

Hgb greater than or equal to 8g/dl (transfusion acceptable)

No history of abnormal bleeding tendency.

Patients must be able to give informed consent

EXCLUSION CRITERIA:

Prior allogeneic stem cell transplantation

Hypertension not adequately controlled by 3 or less medications.

Clinically significant cardiac pathology: myocardial infarction within 6 months prior to
enrollment, Class III or IV heart failure according to NYHY, uncontrolled angina, severe
uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia
or active conduction system abnormalities. Specifically, any history of cardio-vascular
pathology or symptoms, not clearly fitting this exclusion criterion will prompt an
evaluation by a Clinical Center Cardiologist and eligibility will be considered on a
case-by-case basis. Should the cardiologist deem the patient's findings on work-up to be
not clinically significant pathology, the patient will have met this exclusion criterion.

Patients with a history of coronary artery bypass grafting or angioplasty will receive a
cardiology evaluation and be considered on a case-by-case basis.

Active hepatitis B or C infection

HIV seropositive, with positive confirmatory nucleic acid test

Patients known or found to be pregnant.

Patients of childbearing age who are unwilling to practice contraception.

Patients may be excluded at the discretion of the PI/LAI if it is deemed that allowing
participation would represent an unacceptable medical or psychiatric risk.