Observational Study of B-Cell Non Hodgkin Lymphomas (NHL) in Patients With Hepatitis C Virus
Main objectives are:
- Description of the clinical and histological characteristics, treatment and evolution
of these NHL.
- Study their physiopathology by immunological, virologic and molecular studies.
The study included prospective or retrospective patients with B- Cell Non-Hodgkin lymphomas
(NHL) associated with chronic hepatitis C. The patients are diagnosed or in remission of
lymphoma, in relapse or failure of treatments.
The enrolment period is 6 years and the total study lasts 8 years.
- "Prospective patients" are followed every 6 months during one year, and all the years
during 2 or 5 years.
- "Retropective patients" are followed all the years during 2 or 5 years. At each
follow-up, a blood sample of 50ml is withdrawn allowing ancillary studies.
The enrollment is estimated at 140 patients.
Observational Model: Case-Only
presentation of NHL and HCV infection, and treatments of NHL and HCV infection
the presentation of NHL and HCV infection is done by clinical,histological and biological characteristics
at the first visit (Day 0)
Olivier HERMINE, PU-PH
Hôpital Necker (Paris 15è), Service d'hématologie
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
ANRS HC13 Lympho C