Inclusion Criteria:

- Written informed consent prior to any study activities

- Age 18-75 years old

- Histological biopsy confirming oral squamous cell carcinoma (tongue, gingiva, buccal
mucosa, floor of mouth, palate, and retromolar region)

- Clinical stage III/IVA (T1-2, N1-2, M0 or T3-4, N0-2, M0, UICC 2002), resectable
lesions

- Karnofsky performance status (KPS) > 60

- Adequate hematologic function: white blood cell > 3,000/mm^3, hemoglobin > 8g/L,
platelet count > 80,000/mm^3

- Hepatic function: ALAT/ASAT < 2.5 times the upper limit of normal (ULN), bilirubin <
1.5 times ULN

- Renal function: serum creatinine < 1.5 x ULN

- Life expectancy ≥ 6 months

Exclusion Criteria:

- Evidence of distant metastatic disease and other cancers

- Surgical procedure of the primary tumor or lymph nodes (except diagnostic biopsy)
before study treatment

- Previous radiotherapy for the primary tumor or lymph nodes

- Prior chemotherapy or immunotherapy for the primary tumor

- Other previous malignancy within 5 years

- Systematic diseases history of severe pulmonary or cardiac diseases

- Creatinine Clearance < 30 ml/min

- Legal incapacity or limited legal capacity

- Pregnancy (confirmed by serum or urine β-HCG) or lactation period