Trial Information

Assessment of Reorganization and Plasticity of Eloquent Function in Patients With Brain Tumors

Any patient with a primary or metastatic brain tumor in or near an eloquent area would be
eligible for participation in the study assuming no contraindications to any of the studies
or operative procedure.

Pre-operative:

Evaluation will include clinical evaluation, neuropsychological testing, MRI brain with and
without contrast, fMRI, DTI tractograms, and MEG studies as well as standard pre-operative
work-up.

Intra-operative:

All non-invasive pre-operative mapping data will be incorporated into the operative
procedure with the imaging tools that we routinely use during neurosurgical procedures.
Patients will have awake mapping performed. Our usual standards of care will be followed
during craniotomy, mapping, and tumor resection or biopsy.

Post-operative:

Patients will have routine post-operative care and assessment consisting of clinical
examinations and imaging obtained within 24 hours post resection. They will have routine
follow-up outpatient appointments after surgery which will include neurologic assessment and
follow-up imaging (MRI with and without contrast) for their tumors as appropriate. The
experimental portion of the protocol is incorporating repeat neuropsychological testing and
mapping studies (fMRI, DTI, MEG) studies at 2 and 6 months post-surgery into their routine
follow-up.