Inclusion Criteria:

1. Patients with histologically confirmed CRC, who are scheduled to start or are getting
first line chemotherapy for metastatic disease

2. Age > 18

3. Metastatic disease (including locally advanced disease not amenable with surgery
and/or (chemo)radiotherapy)

4. Signed written informed consent according to ICH/GCP and the local regulations
(approved by the Independent Ethics Committee [IEC]) will be obtained prior to study

5. No informed consent will be obtained from patients participating in the data
collection study obtaining data from hospital charts. No blood sampling, nor
contacting of patients will be performed.