Trial Information

Multi-center Prospective Observational Study for the Validation of Preoperative Low-risk Criteria for Lymph Node Metastasis in Endometrial Cancer

The Korean Gynecologic Oncology Group (KGOG) undertook a multi-center retrospective study to
develop a preoperative prediction model for lymph node metastasis in endometrial cancer
(KGOG-2014). This retrospective multi-center study showed that the accurate identification
of a low-risk group for lymph node metastasis among the patients with endometrial cancer can
be achieved with the new criteria using preoperative MRI and serum CA-125 assay. In this
study, serum CA125 levels and three MRI parameters (deep myometrial invasion, lymph node
enlargement, and extension beyond uterine corpus) were found to be independent risk factors
for nodal metastasis. Based on the success of KGOG-2014, Korean Gynecologic Oncology Group
initiated this prospective, multi-center observational study to validate our prior
prediction model.