Assessment of MicroRNA Expression in Acute Graft-versus-Host Disease
18 Years
N/A
Both
Acute Graft-versus-Host Disease, Allogeneic Stem Cell Transplant
Trial Information
Assessment of MicroRNA Expression in Acute Graft-versus-Host Disease
The purpose of this study is to examine whether the expression levels of a novel class of
molecules, called microRNAs, are associated with acute graft-versus-host disease frequency
and severity. Acute graft-versus-host disease is a Acute GVHD is a medical condition that
can become very serious. It happens when the donor cells attack and damage your tissues
after transplant.
Inclusion Criteria:
- Patients who are receiving allogeneic stem cell transplantation at the Ohio State
University Blood and Marrow Transplantation program are eligible and will be
consented for the study.
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Outcome Measure:
Measure miR-155 expression levels over time in the serum from patients receiving allogeneic stem cell transplant, and evaluate if miR-155 expression can predict development of aGVHD (Acute Graft-versus-Host Disease)
Outcome Time Frame:
up to 14 weeks
Safety Issue:
No
Principal Investigator
Yvonne Efebera, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Ohio State University
Authority:
United States: Institutional Review Board
Study ID:
OSU-11002
NCT ID:
NCT01521039
Start Date:
February 2012
Completion Date:
December 2015
Related Keywords:
- Acute Graft-versus-Host Disease
- Allogeneic Stem Cell Transplant
- aGVHD
- Acute Graft-versus-Host Disease
- allogeneic stem cell transplantation
- Hematopoietic stem cell transplation
- MicroRNA Expression
- Graft vs Host Disease
Name | Location |
|---|---|
| Ohio State University Medical Center | Columbus, Ohio 43210 |
