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Assessment of MicroRNA Expression in Acute Graft-versus-Host Disease


N/A
18 Years
N/A
Open (Enrolling)
Both
Acute Graft-versus-Host Disease, Allogeneic Stem Cell Transplant

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Trial Information

Assessment of MicroRNA Expression in Acute Graft-versus-Host Disease


The purpose of this study is to examine whether the expression levels of a novel class of
molecules, called microRNAs, are associated with acute graft-versus-host disease frequency
and severity. Acute graft-versus-host disease is a Acute GVHD is a medical condition that
can become very serious. It happens when the donor cells attack and damage your tissues
after transplant.


Inclusion Criteria:



- Patients who are receiving allogeneic stem cell transplantation at the Ohio State
University Blood and Marrow Transplantation program are eligible and will be
consented for the study.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Measure miR-155 expression levels over time in the serum from patients receiving allogeneic stem cell transplant, and evaluate if miR-155 expression can predict development of aGVHD (Acute Graft-versus-Host Disease)

Outcome Time Frame:

up to 14 weeks

Safety Issue:

No

Principal Investigator

Yvonne Efebera, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Ohio State University

Authority:

United States: Institutional Review Board

Study ID:

OSU-11002

NCT ID:

NCT01521039

Start Date:

February 2012

Completion Date:

December 2015

Related Keywords:

  • Acute Graft-versus-Host Disease
  • Allogeneic Stem Cell Transplant
  • aGVHD
  • Acute Graft-versus-Host Disease
  • allogeneic stem cell transplantation
  • Hematopoietic stem cell transplation
  • MicroRNA Expression
  • Graft vs Host Disease

Name

Location

Ohio State University Medical CenterColumbus, Ohio  43210