Inclusion Criteria:

- Patient aged 18 years old and under 70

- Carcinoma oral cavity, pharyngolaryngeal or without lymphadenopathy door

- Patient treated by one of the following diagrams

- radiotherapy alone

- postoperative radiotherapy + / - sensitized platinum (cisplatin or carboplatin)

- ar chemoradiation 5-FU and platinum (the Cetuximab is not allowed)

- diagram organ preservation (induction chemotherapy and radiotherapy in
responders)

- Untreated patients

- Patient should receive conventional radiotherapy or tomotherapy

- Adapted stomatological care

- Life expectancy > 3 months

- WHO score < 2

- Patient stable, not having the time of the examination of evidence of recurrent or
progressive malignancy other

- - For patients with an indication of chemotherapy combined with
radiotherapy,biological assessments compatible with chemotherapy:

- WBC > 3000/mm3, Polynuclear > 2000/mm3,Platelets > 150,000/mm3, Creatinine less
than 2 times normal; Bilirubin less than 2.5 times normal

- Patient fluent in French

- Affiliation to a system of social security

- Patient has given written consent

Exclusion Criteria:

- Patient with a history of malignancy, outside a basal cell carcinoma or cervical
cancer treated and cured

- Patient has at the time of examination signs of recurrence or other neoplasia
scalable

- Patient with a history of prior chemotherapy or radiation therapy with the exception
of the scheme of organ preservation (induction chemotherapy before radiation)

- For patients with an indication of chemotherapy combined with radiotherapy,
contraindication to treatment with specific platinum (cisplatin or carboplatin) with
or without 5 Fluorouracil

- Infectious diseases uncontrolled

- Patient is pregnant or lactating or absence of contraception during their
reproductive

- Patient hypertensive unbalanced under antihypertensive treatment

- Uncontrolled cardiac disease

- Patients with renal or hepatic

- Known allergy to any component of Ialuset ®

- Patient deprived of liberty under guardianship

- Any medical condition or psychological associate that could compromise the patient's
ability to participate in the study

- Inability to undergo medical test for geographical, social or psychological