Genome Based Outcome Prediction in High Risk Neuroblastoma
- To test the correlation of a previously published microarray gene expression signature
with the gene expression obtained with the nCounter™ Analysis System using RNA isolated
from formalin-fixed, paraffin-embedded (FFPE), high-risk neuroblastoma samples.
- To construct, test, and validate a novel robust classifier that can be readily
integrated into the clinic.
OUTLINE: This is a multicenter study.
RNA samples extracted from paraffin-embedded tissue are analyzed for gene signature
expression levels by nCounter™ Analysis System and correlated with published microarray
expression data. Results are then used to develop a refined gene-expression-profile
classifier of ultra high-risk neuroblastoma.
Linear correlation between the nCounter™ Analysis System and the expression data obtained in microarray platforms
Susan L. Cohn, MD
University of Chicago Comer Children's Hospital
United States: Federal Government