A Pilot Study of Changes in Hepatic Function During Radiation Therapy Using Hepatobiliary SPECT
18 Years
N/A
Both
Hepatocellular Carcinoma
Trial Information
A Pilot Study of Changes in Hepatic Function During Radiation Therapy Using Hepatobiliary SPECT
Early, but subclinical physiologic changes in the liver may be associated with the future
development of RILD. There are currently limited data on how a local change in hepatic
function associates with regional radiation dose, and how the change of hepatic function
during and after radiation therapy (RT) associates with RILD. In the present study, a
radiological methodology that is minimally invasive will be used to measure volumetric
hepatic functions in patients with intrahepatic malignancies before, during, and after a
course of fractioned radiation therapy.
Inclusion Criteria:
- cancer patients undergoing radiation of the Liver
- women and men who agree to avoid pregnancy
- life expectancy of at least 6 months
Exclusion Criteria:
- pregnant women
- breatsfeeding women
- prisoners
Type of Study:
Observational
Study Design:
Observational Model: Case-Only, Time Perspective: Prospective
Outcome Measure:
Changes in hepatobiliary single photon emission tomography (SPECT) after radiation therapy
Outcome Description:
Changes in SPECT, which reflect hepatocyte function, will be correlated with specific regions of radiation dose to determine a relationship between dose and radiation-induced damage.
Outcome Time Frame:
6 months
Safety Issue:
No
Principal Investigator
Mary Feng, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of Michigan Cancer Center
Authority:
United States: Institutional Review Board
Study ID:
UMCC 2007-110
NCT ID:
NCT01519232
Start Date:
August 2008
Completion Date:
January 2016
Related Keywords:
- Hepatocellular Carcinoma
- hepatocellular carcinoma
- Carcinoma
- Carcinoma, Hepatocellular
Name | Location |
|---|---|
| University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan 48109-0752 |
