A Pilot Study of Changes in Hepatic Function During Radiation Therapy Using Hepatobiliary SPECT
Early, but subclinical physiologic changes in the liver may be associated with the future
development of RILD. There are currently limited data on how a local change in hepatic
function associates with regional radiation dose, and how the change of hepatic function
during and after radiation therapy (RT) associates with RILD. In the present study, a
radiological methodology that is minimally invasive will be used to measure volumetric
hepatic functions in patients with intrahepatic malignancies before, during, and after a
course of fractioned radiation therapy.
Observational Model: Case-Only, Time Perspective: Prospective
Changes in hepatobiliary single photon emission tomography (SPECT) after radiation therapy
Changes in SPECT, which reflect hepatocyte function, will be correlated with specific regions of radiation dose to determine a relationship between dose and radiation-induced damage.
Mary Feng, MD
University of Michigan Cancer Center
United States: Institutional Review Board
|University of Michigan Comprehensive Cancer Center||Ann Arbor, Michigan 48109-0752|