Assessment Of Liver Function in Patients Undergoing Hepatic Irradiation
Following intravenous injection, IC-GREEN is rapidly bound to plasma protein, of which
albumin is the principle carrier (95%). IC-GREEN is taken up from the plasma almost
exclusively by the hepatic parenchymal cells and is secreted entirely into the bile. It
undergoes no significant extrahepatic or enterohepatic circulation. Simultaneous arterial
and venous blood estimations have shown negligible renal, peripheral, lung or cerebro-spinal
uptake of the dye. Therefore, the serum clearance rate (determined from serial serum
concentration measurements at various times after intravenous injection) can serve as a
useful index of liver function.
Observational Model: Case-Only, Time Perspective: Prospective
Baseline IC-GREEN elimination
Most subjects will have five IC-GREEN assessments. Graphical displays will be used to choose the form of a time-dependent model of IC-GREEN elimination. A mixed, possibly nonlinear model, with patient as random effect, will be fit to the data by the maximum likelihood principle. Profile confidence intervals for the parameters will be determined.
Mary Feng, MD
University of Michigan Cancer Center
United States: Institutional Review Board
|University of Michigan Comprehensive Cancer Center||Ann Arbor, Michigan 48109-0752|