Trial Information

Long Term Diabetes Improvement After Cancer Gastrectomy and Colectomy

In a prospective protocol with retrospective information, patients (N=240) undergoing
bariatric Roux-en-Y gastric bypass (n=80), cancer subtotal or total gastrectomy (n=80) and
right colectomy or rectosigmoidectomy (n=80) with follow-up >3 years free of disease, with
or without previously impaired fasting blood glucose, will be recruited. Patients will be
submitted to a questionnaire involving diet, diagnosis of diabetes and glucose-lowering
drugs, body weight and other clinical items. Preoperative information available in the
hospital system will be completed and current findings will be updated, including body mass
index and biochemical measurements. Using the outcomes of the bariatric population as
benchmark, both concerning diabetics that were ameliorated and nondiabetics that progressed
to new-onset diabetes,results in the other groups will be compared. The study should answer
whether gastric and colorectal surgery for cancer 1) Are beneficial for established
diabetes; 2) Attenuate the conversion of normal patients to diabetes, both within a
follow-up period of 3- 12 years;