Inclusion Criteria:
- Newly diagnosed, histologically confirmed stage I-III breast cancer
- Planning to undergo definitive surgical management with lumpectomy or mastectomy with
in the next 8 weeks.
- Willing and able to participate in the intervention for at least 3 weeks prior to
surgery.
- ECOG performance status of 0 or 1
- Approval by oncologist or surgeon
- Willingness to be randomized.
- English speaking and able to read English
Exclusion Criteria:
- Concurrent other malignancy or history of other malignancy treated within the past 3
years (other than non-melanoma skin cancer or in situ cervical cancer)
- Presence of metastatic disease
- Scheduled to receive any form of neoadjuvant cancer therapy
- Locally advanced breast cancer not amenable to primary surgery
- History of prior ipsilateral breast cancer
- Taking tamoxifen, raloxifene or an aromatase inhibitor at the time of breast cancer
diagnosis
- Absolute contraindications to maximal exercise testing as recommended by the American
Thoracic Society
- Any condition which in the investigator's opinion makes the subject unsuitable for
study participation
- Participating in another clinical study with competing study outcomes
- Pregnant (i.e., positive beta-HCG) or breast feeding
- Unable to comply with protocol and/or not available for follow-up assessments
- Participation in more than 90 minutes a week of moderate-intensity recreational
activity (not including activities such as gardening, bowling, golfing with a cart)
as assessed by the Leisure Score Index of Godin Leisure- Time Exercise Questionnaire
(LSI) (Appendix I) or recent participation (past 6 months) in two or more strength
training sessions per week.
- Diabetes mellitus requiring insulin or oral agents; patients with diet-controlled
diabetes will be allowed to participate