Inclusion Criteria:

1. Male, 35-80 years old

2. Patients who present for a routine check-up

3. Patients who present for the evaluation of an abnormal exam or test (elevated PSA,
abnormal DRE, etc.)

4. Patients who present for the evaluation of a palpable nodule or induration on
prostate exam

5. Patients may present with a biopsy proven prostate cancer from outside physician for
inclusion into arms 2 or 3

6. For group 1 a negative prostate biopsy

Exclusion Criteria:

1. Patient < 35 or > 81 years of age

2. Concurrent eye infection or trauma

3. Active conjunctivitis

4. Abnormal production of tears (too much or too little)

5. Any other conditions the PI or staff feels will not fulfill the criteria for study
entry or will place the subject in a harmful environment

6. Atypia on prostate biopsy report