Inclusion Criteria:

- Women fulfilled two out of three diagnostic criteria for PCOS, according to the 2003
Rotterdam Consensus conference

- Women with PCOS, insulin resistance, acne, hirsutism and seborrhea

Exclusion Criteria:

- Women with pre-existing secondary endocrine disorders

- Women wishing to conceive during the next 12 months

- Women with contradictions to oral contraceptive use

- Women with personal history of hypertension, diabetes mellitus or cardiovascular
disorders

- Women who received treatment with oral contraceptives, or other drugs for the
previous 6 months before entering the study.