Phase 1

Inclusion Criteria:

1. Age >= 40 years old

2. Gender: males and females

3. Provide written informed consent

4. Satisfactory compliance

Phase 2

Inclusion Criteria:

1. Age >= 40 and =< 75 years old

2. Gender: males and females

3. Provide written informed consent

4. Satisfactory compliance

Exclusion Criteria:

1. History of cancer;

2. History of LADA and other autoimmunity diseases;

3. Acute diabetic complication, acidosis, etc;

4. Moderate to severe liver, kidney dysfunction, i.e. ALT/AST > 2.5 times the upper
limit of normal range or Ccr < 25ml/min;

5. Any other condition or major systemic diseases that the investigator feels would
interfere with trial participation or evaluation of results.